| 'Body Clock' Chemical Could Help Fight Mesothelioma |
One of the chemicals responsible for helping establish the body's circadian rhythms may also help doctors fight mesothelioma.
BMAL1 is an important component of the circadian clock, the internal biochemical 'clock' that regulates such important body functions as heart rhythm, wake-sleep cycles, and hunger. Previous studies have found that mesothelioma cells produce more BMAL1 than healthy cells. Now, a group of Japanese doctors is proposing that the extra BMAL1 in mesothelioma cells could serve as a target for anti-cancer drugs.
Malignant pleural mesothelioma – the most common form of mesothelioma – is a cancer of the mesothelial lining around the lungs. It is caused by exposure to asbestos and, to date, there is no consistently affective treatment. The irregular shape of mesothelioma tumors, their location so close to vital organs, and the fact that they tend to grow quickly make mesothelioma a challenge to treat. If a molecule could be 'programmed' to carry a drug into cells that overexpress BMAL1, it might be possible to destroy mesothelioma cells from the inside out while leaving nearby healthy cells intact.
To test the validity of their idea, the Japanese researchers exposed mesothelioma cell samples to a serum shock designed to disrupt normal circadian rhythms. In the healthy mesothelial cells, the shock caused a change in BMAL1 expression. But the mesothelioma cells continued to express extra BMAL1, suggesting that these cells do not follow same circadian rhythms as healthy cells.
When the researchers deliberately reduced the amount of BMAL1 in the mesothelioma cells, they observed cell cycle disruption and an increase in cell death. In fact, the depletion of BMAL1 caused a range of "drastic morphological changes", including multiple nuclei, in the mesothelioma cells. The cells that contained the most BMAL1 were affected the most.
In a report on their findings in the International Journal of Cancer, the researchers conclude, "Taken together, these findings indicate that BMAL1 has a critical role in malignant pleural mesothelioma and could serve as an attractive therapeutic target for MPM (mesothelioma). " Further study will be needed to confirm the findings.
Approximately 2,500 people are diagnosed with mesothelioma each year in the U.S.
Source:
Elshazley, M et al, "The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma", April 17, 2012, International Journal of Cancer, Epub ahead of print.
© Surviving Mesothelioma and Cancer Monthly. All rights reserved.
DISCLAIMER: : Surviving Mesothelioma® is registered with the United States Patent and Trademark Office by Cancer Monthly, Inc. and the website is owned and managed by Cancer Monthly Inc. All of the information provided on this website or by any employee or contractor of Cancer Monthly is for informational purposes only. This website is not a substitute for professional medical advice, examination, diagnosis or treatment. This website should not be used for diagnosing or treating a health problem or disease and it is not a substitute for professional care. You should always seek the advice of your physician or other qualified health professional before starting any new treatment or making any changes to an existing treatment. You should not delay in seeking or disregard medical advice based on information on this website or by any employee or contractor of Cancer Monthly.
